The Click event is fired when the user releases the left mouse button over the control. Use a MouseDown or MouseUp event procedure to specify actions that will occur when a mouse button is pressed or released. Unlike the Click and DblClick events, MouseDown and MouseUp events lets you distinguish between the left, right, and middle mouse buttons. You can also write code for mouse-keyboard combinations that use the SHIFT, CTRL, and ALT keyboard modifiers. If you have a column of hyperlink cells ( CellHyperLink property is True ) you should use HyperLinkClick event. The AnchorClick event notifies your application that the user clicks an <a> anchor element.